The possible role of oxytocin in neuropsychiatric disorders
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Keywords

Oxytocin
Autism
Compulsive Personality Disorder
Mood
Anxiety
Post Traumatic Stress Disorder
Addiction
Eating Disorders
Schizophrenia

Abstract

Oxytocin (OT) is a peptide hormone unique to mammals, typically involved in activities characteristic of this vertebrate class, such as labour and lactation. Evidence suggests a role of OT even in most complex activities, including child attachment, maternal care, couple bonding, emotional and social behaviors. Furthermore, it seems to contribute to the modulation of stress responses, learning, and memory processes, as well as to the connection of social signals with cognition, behaviors and reward. For this reason, for years there has been a debate on the possible contribution of the OT system in the pathophysiology of different neuropsychiatric disorders, including autism spectrum disorders, obsessive-compulsive disorder, depression, anxiety disorders, post-traumatic stress disorder, eating disorders, addiction, and schizophrenia. In this article, we describe the most relevant findings on OT system abnormalities in the aforementioned disorders, with a focus on possible therapeutic implications.

https://doi.org/10.48037/mbmj.v8i10.1311
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References

Marazziti D, Bani A, Casamassima F, et al. Oxytocin: An old hormone for new avenues. Clin. Neuropsychiatry 2006;3(5):302-321

Marazziti D, Catena Dell’osso M. The role of oxytocin in neuropsychiatric disorders. Curr. Med. Chem. 2008;15(7):698-704. Available from: https://doi.org/10.2174/092986708783885291

Misrani A, Tabassum S, Long C. Oxytocin system in neuropsychiatric disorders: Old concept, new insights. Sheng Li Xue Bao 2017;69(2):196-206

Yamasue H, Domes G. Oxytocin and autism spectrum disorders. Curr Top Behav Neurosci 2018;35:449-65. Available from: https://doi.org/10.1007/7854_2017_24.

Husarova VM, Lakatosova S, Pivovarciova A, et al. Plasma oxytocin in children with autism and its correlations with behavioral parameters inchildren and parents. Psychiatry Investig. 2016;13(2):174-83. Available from: https://doi.org/10.4306/pi.2016.13.2.174

Guastella AJ, Einfeld SL, Gray KM, et al. Intranasal oxytocin improves emotion recognition for youth with autism spectrum disorders. Biol. Psychiatry. 2010;67(7):692-4. Available from: https://doi.org/10.1016/j.biopsych.2009.09.020

Gauthier C, Doyen C, Amado I, Lôo H, Gaillard R. Therapeutic effects of oxytocin in autism: current status of the research. Encephale. 2016;42(1):24-31. Available from: https://doi.org/10.1016/j.encep.2015.07.006

Chetcuti S, Sammut E, Sammut M, Calleja-Agius J. The other face of oxytocin. International Journal of Prenatal & Life Sciences. 2019;3(3). Available from: https://doi.org/10.24946/IJPLS

Cochran DM, Fallon D, Hill M, Frazier JA. The role of oxytocin in psychiatric disorders: a review of biological and therapeutic research findings. Harv. Rev. Psychiatry. 2013;21(5):219-47. Available from: https://doi.org/10.1097/HRP.0b013e3182a75b7d

Marazziti D, Baroni S, Giannaccini G, et al. Plasma oxytocin levels in untreated adult obsessive-compulsive disorder patients. Neuropsychobiology. 2015;72(2):74-80. Available from: https://doi.org/10.1159/000438756

Ozsoy S, Esel E, Kula M. Serum oxytocin levels in patients with depression and the effects of gender and antidepressant treatment. Psychiatry Res. 2009;169(3):249-52. Available from: https://doi.org/10.1016/j.psychres.2008.06.034

Scantamburlo G, Hansenne M, Fuchs S, et al. Plasma oxytocin levels and anxiety in patients with major depression. Psychoneuroendocrinology. 2007;32(4):407-10. Available from: https://doi.org/10.1016/j.psyneuen.2007.01.009

Bell CJ, Nicholson H, Mulder RT, Luty SE, Joyce PR. Plasma oxytocin levels in depression and their correlation with the temperament dimension of reward dependence. J. Psychopharmacol 2006;20(5):656-60. Available from: https://doi.org/10.1177/0269881106060512

Cyranowski JM, Hofkens TL, Frank E, Seltman H, Cai H-M, Amico JA. Evidence of dysregulated peripheral oxytocin release among depressed women. Psychosom Med 2008;70(9):967-75. Available from: https://doi.org/10.1097/PSY.0b013e318188ade4

Labuschagne I, Phan KL, Wood A, et al. Oxytocin attenuates amygdala reactivity to fear in generalized social anxiety disorder. Neuropsychopharmacology 2010;35(12):2403-13. Available from: https://doi.org/10.1038/npp.2010.123

Sippel L, Allington C, Pietrzak R, Harpaz-Rotem I, Mayes L, Olff M. Oxytocin and stress-related disorders: neurobiological mechanisms and treatment opportunities. Chronic Stress 2017;1:1-15. Available from: https://doi.org/10.1177/2470547016687996

Marazziti D, Baroni S, Mucci F, et al. Sex-related differences in plasma oxytocin levels in humans. Clin Pract Epidemiol Ment Health 2019;15:58-63. Available from: https://doi.org/10.2174/1745017901915010058

Lee MR, Rohn MC, Tanda G, Leggio L. Targeting the oxytocin system to treat addictive disorders: rationale and progress to date. CNS Drugs 2016;30(2):109-23. Available from:https://doi.org/10.1007/s40263-016-0313-z

Lee MR, Weerts EM. Oxytocin for the treatment of drug and alcohol use disorders. Behav Pharmacol 2016;27(8):640-8. Available from: https://doi.org/10.1097/FBP.0000000000000258

Joseph JE, McRae-Clark A, Sherman BJ, Baker NL, Moran-Santa Maria M, Brady KT. Neural correlates of oxytocin and cue reactivity in cocaine-dependent men and women with and without childhood trauma. Psychopharmacology 2019 (online ahead of print). Available from: https://doi.org/10.1007/s00213-019-05360-7

Giel K, Zipfel S, Hallschmid M. Oxytocin and eating disorders: a narrative review on emerging findings and perspectives. Curr Neuropharmacol 2018;16(8):1111-21. Available from: https://doi.org/10.2174/1570159X15666171128143158

Crucianelli L, Serpell L, Paloyelis Y, et al. The effect of intranasal oxytocin on the perception of affective touch and multisensory integration in anorexia nervosa: protocol for a double-blind placebo-controlled crossover study. BMJ Open 2019;9(3):e024913. Available from: https://doi.org/10.1136/bmjopen-2018-024913

Souza RP, de Luca V, Meltzer HY, Lieberman JA, Kennedy JL. Schizophrenia severity and clozapine treatment outcome association with oxytocinergic genes. Int. J. Neuropsychopharmacol 2010;13(6):793-8. Available from: https://doi.org/10.1017/S1461145710000167

Rosenfeld AJ, Lieberman JA, Jarskog LF. Oxytocin, dopamine, and the amygdala: a neurofunctional model of social cognitive deficits in schizophrenia. Schizophr Bull 2011;37(5):1077-87. Available from: https://doi.org/10.1093/schbul/sbq015.

Rubin LH, Carter CS, Drogos L, Pournajafi-Nazarloo H, Sweeney JA, Maki PM. Peripheral oxytocin is associated with reduced symptom severity in schizophrenia. Schizophr Res 2010;124(1-3):13-21. Available from: https://doi.org/10.1016/j.schres.2010.09.014